Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 1/20 | 0.49 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.49 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9662930 | 0.87 | CYP19A1 (0.54) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9664986 | 0.85 | CYP11B1 (0.56) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| Water SCHEMBL9664102 | 0.84 | CYP11B1 (0.54) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9662157 | 0.82 | RAB9A (0.55) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9663840 | 0.79 | CYP11B1 (0.49) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9663552 | 0.78 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP17A1CYP19A1CYP1A2 | |
| SCHEMBL9663603 | 0.78 | CYP11B1 (0.47) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9664806 | 0.76 | KCNH2 (0.50) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9663721 | 0.76 | CYP11B1 (0.49) | KCNH2CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL9663727 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP17A1CYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |