Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 17/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663438 | 0.90 | CYP17A1 (0.61) | CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9663469 | 0.84 | CYP17A1 (0.59) | CYP17A1CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL9663529 | 0.79 | CYP17A1 (0.61) | CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL8973924 | 0.77 | CYP17A1 (0.75) | CYP17A1CYP19A1 | |
| SCHEMBL973378 | 0.76 | CYP17A1 (0.49) | CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL3805066 | 0.76 | CYP19A1 (0.62) | CYP17A1CYP19A1 | |
| SCHEMBL28553199 | 0.75 | CYP17A1 (0.64) | CYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9662998 | 0.75 | CYP17A1 (0.58) | CYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8973344 | 0.75 | CYP17A1 (0.71) | CYP17A1CYP3A4CYP19A1 | |
| SCHEMBL9910964 | 0.74 | CYP17A1 (0.84) | CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020903-C | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THE PREPARATION THEREFOR | JANSSEN PHARMACEUTICA NV (BE) | 1993-05-26 | — | — | CN | disclosed |
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| CN-87106423-A | Novel (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and process for their preparation | — | 1988-04-20 | — | — | CN | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |