Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444721 | 0.87 | CTNNB1 (0.44) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL9665981 | 0.85 | CTNNB1 (0.45) | CTNNB1TDP1L3MBTL1TACR1ATM | |
| SCHEMBL6443448 | 0.84 | CTSS (0.46) | CTNNB1TDP1L3MBTL1TACR1ATM | |
| SCHEMBL7279499 | 0.82 | CTNNB1 (0.45) | CTNNB1TDP1L3MBTL1TACR1ATM | |
| SCHEMBL29253169 | 0.81 | CTNNB1 (0.51) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL9666889 | 0.78 | CTNNB1 (0.52) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL9666892 | 0.78 | CTNNB1 (0.52) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL10390076 | 0.78 | CTNNB1 (0.52) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL6622742 | 0.77 | CTNNB1 (0.48) | CTNNB1TDP1L3MBTL1TACR1SIRT5 | |
| SCHEMBL6447126 | 0.76 | CTSS (0.41) | CTNNB1TDP1L3MBTL1TACR1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184550-B1 | 5-AMINO-4-HYDROXY VALERYL AMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-03-18 | — | — | EP | disclosed |
| US-4931591-A | Novel 5-amino-4-hydroxyvaleryl derivatives | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | disclosed |