Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.49 |
| ▸ | F2 | P00734 | 5/20 | 0.48 |
| ▸ | PLG | P00747 | 5/20 | 0.48 |
| ▸ | PROC | P04070 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.45 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954806 | 0.92 | F10 (0.52) | F10F2PLGPROCPLAU | |
| SCHEMBL8954844 | 0.82 | F10 (0.50) | F10F2PLGPROCPLAU | |
| SCHEMBL8954760 | 0.81 | F10 (0.48) | F10F2PLGPROCPLAU | |
| SCHEMBL8954943 | 0.81 | F10 (0.49) | F10F2PLGPROCPLAU | |
| Bicarbonate SCHEMBL9665131 | 0.80 | F10 (0.57) | F10F2PLGPLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL8954922 | 0.78 | F10 (0.51) | F10F2PLGPROCPLAU | |
| SCHEMBL8954706 | 0.78 | F10 (0.52) | F10F2PLGPROCPLAU | |
| SCHEMBL8954951 | 0.77 | PLG (0.51) | F10F2PLGPROCPLAU | |
| SCHEMBL8954767 | 0.76 | F10 (0.50) | F10F2PLGPROCPLAU | |
| SCHEMBL8954880 | 0.76 | F10 (0.52) | F10F2PLGPROCPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511347-A1 | META-SUBSTITUTED PHENYL ALANINE DERIVATIVES | Pentapharm A.G. (CH) | 1992-11-04 | — | — | EP | disclosed |
| WO-1992008709-A1 | META-SUBSTITUTED PHENYL ALANINE DERIVATIVES | PENTAPHARM AG (CH) | 1992-05-29 | — | — | WO | disclosed |