Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666453 | 0.82 | KMT2A (0.55) | GAASMN1; SMN2MAOAMAOBSLC6A4 | |
| SCHEMBL10976169 | 0.82 | GAA (0.57) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL11259560 | 0.79 | CYP3A4 (0.44) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL9032873 | 0.79 | HCN4 (0.43) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL11089973 | 0.74 | GAA (0.48) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL14685767 | 0.71 | GAA (0.66) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL15840128 | 0.71 | GAA (1.00) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL11169272 | 0.70 | MAOA (0.84) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL14696925 | 0.70 | GAA (0.68) | GAASMN1; SMN2DRD1DRD4DRD5 | |
| SCHEMBL10601186 | 0.69 | HCN4 (0.43) | GAASMN1; SMN2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259793-B1 | NAPHTHYL DERIVATIVES, MEDICAMENTS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-4871735-A | HYPOTENSIVE, ANTIISCHEMIC AGENTS | DR. KARL THOMAE GMBH | 1989-10-03 | — | — | US | disclosed |
| EP-0259793-A1 | Naphthyl derivatives, medicaments containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |