Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667549 | 0.87 | BRD4 (0.49) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL4891140 | 0.80 | BRD4 (0.50) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL9667697 | 0.77 | BRD4 (0.51) | BRD4ALDH1A1GAAATAD2BMPR1B | |
| SCHEMBL4890085 | 0.76 | BRD4 (0.47) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL10746214 | 0.75 | BRD4 (0.48) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL26646898 | 0.74 | BRD4 (0.56) | BRD4ALDH1A1GAAATAD2BMPR1B | |
| SCHEMBL25014907 | 0.73 | PTPN1 (0.44) | HDAC1HDAC6ALDH1A1PTPN1MAPT | |
| SCHEMBL9665333 | 0.73 | BRD4 (0.55) | BRD4ALDH1A1GAAATAD2BMPR1B | |
| SCHEMBL29868620 | 0.73 | HDAC1 (0.49) | BRD4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL663087 | 0.73 | HDAC1 (0.49) | BRD4HDAC1HDAC8HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4644005-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1987-02-17 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |