Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570035 | 0.89 | SMN1; SMN2 (0.48) | BRD4SMN1; SMN2ALDH1A1SRD5A1SRD5A2 | |
| SCHEMBL9667208 | 0.88 | SRD5A1 (0.51) | BRD4ALDH1A1GAASRD5A1SRD5A2 | |
| SCHEMBL18031362 | 0.86 | CASP3 (0.46) | SMN1; SMN2ALDH1A1SRD5A1SRD5A2CASP3 | |
| SCHEMBL24233398 | 0.84 | CRHR1 (0.45) | SMN1; SMN2ALDH1A1SRD5A1SRD5A2CASP3 | |
| SCHEMBL9376138 | 0.84 | POLB (0.51) | BRD4SMN1; SMN2ALDH1A1GAASRD5A2 | |
| SCHEMBL9666372 | 0.84 | BRD4 (0.51) | BRD4ALDH1A1GAATP53NPC1 | |
| SCHEMBL7234123 | 0.83 | BRD4 (0.50) | BRD4ALDH1A1GAARAB9AATAD2 | |
| SCHEMBL24233521 | 0.81 | NPSR1 (0.50) | SMN1; SMN2ALDH1A1SRD5A1SRD5A2CASP3 | |
| SCHEMBL24233407 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1GAASRD5A1SRD5A2 | |
| SCHEMBL4894332 | 0.81 | BRD4 (0.48) | BRD4SMN1; SMN2ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |