Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667528 | 0.88 | BRD4 (0.47) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL9667595 | 0.88 | ALDH1A1 (0.47) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL9665354 | 0.87 | BRD4 (0.46) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL9665485 | 0.85 | BRD4 (0.44) | BRD4ALDH1A1GAAHDAC1HDAC8 | |
| SCHEMBL11526516 | 0.83 | BRD4 (0.55) | BRD4ALDH1A1GAAHDAC1HDAC8 | |
| SCHEMBL9376138 | 0.82 | POLB (0.51) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL9666372 | 0.82 | BRD4 (0.51) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL4894332 | 0.81 | BRD4 (0.48) | BRD4ALDH1A1GAAHDAC1HDAC8 | |
| SCHEMBL7234123 | 0.81 | BRD4 (0.50) | BRD4ALDH1A1GAAATAD2LMNA | |
| SCHEMBL24430168 | 0.79 | BRD4 (0.55) | BRD4ALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |