Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81650 | 0.76 | NISCH (0.59) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL28425230 | 0.74 | NISCH (0.56) | PDE4APDE4BPDE4CPDE4DNISCH | |
| Hydrochloric Acid SCHEMBL1536214 | 0.74 | NISCH (0.56) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL5454911 | 0.71 | NISCH (0.45) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL10720400 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL10768507 | 0.68 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL20595279 | 0.67 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL20595281 | 0.67 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DNISCH | |
| SCHEMBL28536155 | 0.64 | NPY5R (0.59) | MTORKMT2AKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL29432814 | 0.64 | NISCH (0.42) | PDE4APDE4BPDE4CPDE4DNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229922-B1 | NOVEL 2,2'-BI-1H-IMIDAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0229922-A2 | Novel 2,2'-BI-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-29 | — | — | EP | disclosed |