Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81650 | 0.76 | NISCH (0.59) | NISCHMTORADKIDO1PDE4A | |
| Hydrochloric Acid SCHEMBL1536214 | 0.74 | NISCH (0.56) | NISCHMTORADKIDO1PDE4A | |
| SCHEMBL28425230 | 0.74 | NISCH (0.56) | NISCHMTORADKIDO1PDE4A | |
| SCHEMBL1485376 | 0.72 | NISCH (0.42) | NISCHMTORADKIDO1ALDH1A1 | |
| SCHEMBL9668673 | 0.71 | PDE4A (0.55) | NISCHMTORADKIDO1PDE4A | |
| SCHEMBL3073258 | 0.71 | NPC1 (0.70) | MTORIDO1ALDH1A1KDM4EADORA2A | |
| SCHEMBL5448437 | 0.69 | NISCH (0.46) | NISCHMTORADKIDO1PDE4A | |
| SCHEMBL482165 | 0.68 | NISCH (0.64) | NISCHMTORADKPDE4APDE4B | |
| SCHEMBL5189834 | 0.68 | NISCH (0.42) | NISCHMTORADKIDO1PDE4A | |
| SCHEMBL7165260 | 0.68 | MEN1 (0.47) | NISCHMTORADKIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557989-B2 | Electrochemical affinity biosensor system and methods | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20130213822-A1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8293904-B2 | Electrochemical affinity biosensor system and methods | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8288544-B2 | Electrochemical affinity biosensor system and methods | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| EP-1646637-B1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | ROCHE DIAGNOSTICS GMBH (DE) | 2012-08-15 | — | — | EP | disclosed |
| EP-2465862-A1 | Mononuclear osmium complexes for use in biosensors | Roche Diagniostics GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| US-20120125788-A1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2012-05-24 | — | — | US | disclosed |
| US-20070054317-A1 | Electrochemical affinity biosensor system and methods | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2007-03-08 | — | — | US | disclosed |
| EP-1646637-A2 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | Roche Diagnostics GmbH (DE) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005026178-A2 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | ROCHE DIAGNOSTICS GMBH (DE) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054317-A1 | Electrochemical affinity biosensor system and methods | SIGLEC7, FCGR3B, FCER2 | NISCH 809/4885MTOR 4504/4885ADK 1640/4885 |
| US-20130213822-A1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | SIGLEC7, FCGR3B, FCER2 | NISCH 809/4885MTOR 4504/4885ADK 1640/4885 |
| US-20120125788-A1 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS | SIGLEC7, FCGR3B, FCER2 | NISCH 809/4885MTOR 4504/4885ADK 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.