Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872767 | 0.81 | TSHR (0.47) | TSHRTDP1CYP3A4ALDH1A1MEN1 | |
| SCHEMBL57381 | 0.77 | TDP1 (1.00) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL29475186 | 0.77 | TDP1 (1.00) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL16652207 | 0.76 | TDP1 (0.62) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL1378334 | 0.75 | TDP1 (0.66) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL17599539 | 0.75 | TSHR (0.66) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| Methane SCHEMBL28603558 | 0.75 | TDP1 (0.96) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL30065083 | 0.75 | TSHR (0.66) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL10688399 | 0.75 | TSHR (0.66) | TSHRTDP1CYP3A4ALDH1A1CASP6 | |
| SCHEMBL8688741 | 0.75 | TDP1 (0.66) | TSHRTDP1CYP3A4ALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |