Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 3/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.62 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.62 |
| ▸ | GABRP | O00591 | 1/20 | 0.62 |
| ▸ | GABRD | O14764 | 1/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GRM5 | P41594 | 1/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.62 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.62 |
| ▸ | GABRE | P78334 | 1/20 | 0.62 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.62 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.62 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669559 | 0.91 | GABRG2 (0.62) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9667990 | 0.88 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9667977 | 0.88 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9668417 | 0.88 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669887 | 0.88 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669881 | 0.88 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| Bromide SCHEMBL9669515 | 0.85 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10625307 | 0.85 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10962588 | 0.85 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669755 | 0.85 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285837-B1 | IMIDAZODIAZEPIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-08 | — | — | EP | disclosed |
| US-4863920-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0285837-A1 | Imidazodiazepin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-10-12 | — | — | EP | disclosed |
| US-4775671-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |