Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9101066 | 0.77 | HTT (0.51) | HTTSMN1; SMN2NPSR1KMT2AMAPT | |
| SCHEMBL9694189 | 0.77 | KMT2A (0.50) | SMN1; SMN2NPSR1KMT2AMAPTPOLB | |
| SCHEMBL27647687 | 0.74 | KMT2A (0.64) | SMN1; SMN2KMT2AMAPTPOLBKDM4E | |
| SCHEMBL9320822 | 0.74 | GAA (0.41) | KMT2AMAPTKDM4EALDH1A1CCR6 | |
| SCHEMBL27805730 | 0.73 | KDM4E (0.46) | KMT2AMAPTKDM4EALDH1A1ALOX12 | |
| SCHEMBL21467688 | 0.72 | NPSR1 (1.00) | HTTSMN1; SMN2NPSR1KMT2AMAPT | |
| SCHEMBL28432314 | 0.70 | KMT2A (0.64) | HTTSMN1; SMN2KMT2AMAPTPOLB | |
| SCHEMBL7068629 | 0.69 | MAPT (0.36) | HTTKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL9669206 | 0.69 | KMT2A (0.50) | HTTSMN1; SMN2NPSR1KMT2AMAPT | |
| SCHEMBL13381577 | 0.68 | KMT2A (0.75) | SMN1; SMN2KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | claimed |