Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670719 | 1.00 | MAPT (0.50) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL10574257 | 0.98 | MAPT (0.49) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL25639095 | 0.88 | FYN (0.42) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL25639091 | 0.88 | FYN (0.42) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL29380401 | 0.88 | FYN (0.42) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL25268443 | 0.88 | FYN (0.42) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL29380347 | 0.86 | FYN (0.41) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL25223812 | 0.86 | FYN (0.41) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL6952322 | 0.75 | CYP2A6 (0.41) | NFKB1HSD17B10KDM4EACHE | |
| SCHEMBL6947277 | 0.75 | CYP2A6 (0.41) | NFKB1HSD17B10KDM4EACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0286516-B1 | Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-03-18 | — | — | EP | claimed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | claimed |
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |