Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 8/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10334537 | 0.98 | CYP2A6 (0.40) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL8845141 | 0.98 | CYP2A6 (0.40) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL6952322 | 0.96 | CYP2A6 (0.41) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL12105398 | 0.82 | HTR2C (0.50) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL9672219 | 0.77 | MAOA (0.46) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL25592162 | 0.77 | CYP2A6 (0.41) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL9670865 | 0.76 | MAOA (0.45) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL2149910 | 0.75 | CYP2A6 (0.54) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL6052782 | 0.75 | CYP2A6 (0.47) | CYP2A6HSD17B10KDM4ECYP3A4CYP2D6 | |
| SCHEMBL9670992 | 0.75 | MAPT (0.50) | HSD17B10KDM4ENFKB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765877-B1 | 5,6,7,8-Tetrahyronaphto(2,3-b)furan- and indano(5,6-b)furan-amino-compounds, processes for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | claimed |
| EP-0286516-B1 | Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-03-18 | — | — | EP | claimed |
| JP-9110855-A | — | — | None | — | — | JP | disclosed |
| CN-113853377-B | Heterocyclic compound and organic light-emitting device comprising same | 株式会社LG化学 | 2024-05-14 | — | — | CN | disclosed |
| US-5665765-A | TREATMENT OF PARKINSON'S DISEASE, MEMORY DISORDERS, DISORDERS ASSOCIATED WITH DRUG ABUSE, DEPRESSION, AND PSYCHOTIC STATES | ADIR ET COMPAGNIE (FR) | 1997-09-09 | — | — | US | disclosed |
| US-5665765-A | TREATMENT OF PARKINSON'S DISEASE, MEMORY DISORDERS, DISORDERS ASSOCIATED WITH DRUG ABUSE, DEPRESSION, AND PSYCHOTIC STATES | ADIR ET COMPAGNIE (FR) | 1997-09-09 | — | — | US | disclosed |
| JP-H09110855-A | AMINE COMPOUND OF 5,6,7,8-TETRAHYDRONAPHTHO(2,3-B)FURAN OR INDANO(5,6-B)FURAN, THEIR PRODUCTION AND MEDICINE COMPOSITION CONTAINING THEIR COMPOUNDS | ADIR | 1997-04-28 | — | — | JP | disclosed |