Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 0.84 |
| ▸ | GAA | P10253 | 2/20 | 0.84 |
| ▸ | NPC1 | O15118 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672980 | 0.94 | ALDH1A1 (0.88) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL4871436 | 0.92 | GAA (1.00) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL9476375 | 0.92 | GAA (0.88) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL5901416 | 0.88 | ALDH1A1 (0.77) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL4876345 | 0.86 | ALDH1A1 (0.76) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL4881234 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL950017 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL10004177 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL8832434 | 0.84 | ALDH1A1 (0.73) | ALDH1A1MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL10682470 | 0.84 | ALDH1A1 (0.71) | ALDH1A1MAPTL3MBTL1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190265-B1 | PYRIDONE ESTERS AS INOTROPIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0190265-A4 | PYRIDONE ESTERS AS INOTROPIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1987-07-09 | — | — | EP | disclosed |
| US-4657919-A | CARDIOVASCULAR DISORDERS | E. I. DU PONT DE NEMOURS & CO. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0190265-A1 | PYRIDONE ESTERS AS INOTROPIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1986-08-13 | — | — | EP | disclosed |
| WO-1986001202-A1 | PYRIDONE ESTERS AS INOTROPIC AGENTS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1986-02-27 | — | — | WO | disclosed |
| US-4555517-A | Pyridone esters as inotropic agents | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-11-26 | — | — | US | disclosed |