Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963072 | 1.00 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL5561958 | 0.88 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL31093984 | 0.88 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL13155345 | 0.86 | HDAC3 (0.55) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL13798434 | 0.86 | HDAC3 (0.55) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL963688 | 0.86 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL5133570 | 0.86 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL23733551 | 0.85 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL19638131 | 0.85 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL3034787 | 0.85 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EEF2K, RPS6KA3, MTOR | ALDH1A1 4491/4885SMN1; SMN2 2850/4885KDM4E 1347/4885 |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EEF2K, RPS6KA3, MTOR | ALDH1A1 4491/4885SMN1; SMN2 2850/4885KDM4E 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.