⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859943 | 0.77 | — | — | |
| SCHEMBL28660750 | 0.77 | — | — | |
| SCHEMBL2083052 | 0.69 | — | — | |
| SCHEMBL28392894 | 0.69 | — | — | |
| SCHEMBL18469868 | 0.69 | — | — | |
| SCHEMBL211121 | 0.69 | — | — | |
| SCHEMBL27850617 | 0.69 | — | — | |
| SCHEMBL211122 | 0.69 | — | — | |
| SCHEMBL21048220 | 0.68 | — | — | |
| SCHEMBL21136453 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 198 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168086-B2 | Methods of synthesizing pyrazine compounds | HOFFMANN-LA ROCHE INC. (US) | 2021-11-09 | — | — | US | claimed |
| US-20180334461-A1 | NOVEL PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-22 | — | — | US | claimed |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | TRUSTEES OF BOSTON UNIVERSITY (US) | 2018-10-02 | — | — | US | claimed |
| US-9890167-B2 | Pyrazine compounds for the treatment of infectious diseases | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | claimed |
| EP-3245206-A1 | PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. Hoffmann-La Roche AG (CH) | 2017-11-22 | — | — | EP | claimed |
| US-20160237090-A1 | NOVEL PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2016-08-18 | — | — | US | claimed |
| WO-2016113273-A1 | PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-07-21 | — | — | WO | claimed |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-10 | — | — | US | claimed |
| WO-2014116962-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2014-07-31 | — | — | WO | claimed |
| US-20090286713-A9 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2009-11-19 | — | — | US | claimed |
| EP-1931706-A4 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | BIOTIE THERAPIES CORP (FI) | 2009-05-27 | — | — | EP | claimed |
| US-20090023735-A1 | Sulphonamide Derivatives | BIOTIE THERAPIES CORP. (FI) | 2009-01-22 | — | — | US | claimed |
| US-20080255028-A1 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-16 | — | — | US | claimed |
| EP-1931706-A1 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | Biotie Therapies Corp. (FI) | 2008-06-18 | — | — | EP | claimed |
| EP-1924554-A1 | SULPHONAMIDE DERIVATIVES | Biotie Therapies Corp. (FI) | 2008-05-28 | — | — | EP | claimed |
| WO-2007034035-A1 | SULPHONAMIDE DERIVATIVES | BIOTIE THERAPIES CORPORATION (FI) | 2007-03-29 | — | — | WO | claimed |
| WO-2007031608-A1 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | BIOTIE THERAPIES CORPORATION (FI) | 2007-03-22 | — | — | WO | claimed |
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | claimed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | claimed |
| EP-3957627-B1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | SHIONOGI & CO (JP) | 2024-06-19 | — | — | EP | disclosed |
| EP-4371979-A1 | FORMAMIDE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE CONTROL AGENT | Kumiai Chemical Industry Co., Ltd. (JP) | 2024-05-22 | — | — | EP | disclosed |
| CN-117693500-A | Carboxamide derivative and agricultural/horticultural plant disease control agent | 组合化学工业株式会社 | 2024-03-12 | — | — | CN | disclosed |
| US-11897899-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2024-02-13 | — | — | US | disclosed |
| EP-3495363-B1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | SHIONOGI & CO (JP) | 2023-08-23 | — | — | EP | disclosed |
| EP-3559007-B1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2023-08-16 | — | — | EP | disclosed |
| US-11685740-B2 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2023-06-27 | — | — | US | disclosed |
| WO-2023286855-A1 | FORMAMIDE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE CONTROL AGENT | クミアイ化学工業株式会社 | 2023-01-19 | — | — | WO | disclosed |
| US-11345716-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2022-05-31 | — | — | US | disclosed |
| CN-110072862-B | Bicyclic nitrogen-containing heterocyclic derivative and pharmaceutical composition containing the same | 盐野义制药株式会社 | 2022-05-13 | — | — | CN | disclosed |
| CN-110167946-B | Sulfonamide compounds having TNAP inhibitory activity | 第一三共株式会社 | 2022-04-08 | — | — | CN | disclosed |
| EP-3957627-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Shionogi & Co., Ltd (JP) | 2022-02-23 | — | — | EP | disclosed |
| US-11168086-B2 | Methods of synthesizing pyrazine compounds | HOFFMANN-LA ROCHE INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210317125-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2021-10-14 | — | — | US | disclosed |
| US-20210292283-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2021-09-23 | — | — | US | disclosed |
| US-11066409-B2 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2021-07-20 | — | — | US | disclosed |
| US-11046710-B2 | Sulfonamide compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-29 | — | — | US | disclosed |
| US-11014939-B2 | — | — | 2021-05-25 | — | — | US | disclosed |
| US-20210009607-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT | SHIONOGI & CO., LTD. (JP) | 2021-01-14 | — | — | US | disclosed |
| US-10870660-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2020-12-22 | — | — | US | disclosed |
| US-10774051-B2 | 6-membered heterocyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2020-09-15 | — | — | US | disclosed |
| US-20200087321-A1 | SULFONAMIDE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-03-19 | — | — | US | disclosed |
| US-20200048257-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2020-02-13 | — | — | US | disclosed |
| EP-3559007-A1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-10-30 | — | — | EP | disclosed |
| EP-3319970-B1 | PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2019-08-28 | — | — | EP | disclosed |
| EP-3527568-A1 | BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Shionogi & Co., Ltd (JP) | 2019-08-21 | — | — | EP | disclosed |
| EP-3495363-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | Shionogi & Co., Ltd (JP) | 2019-06-12 | — | — | EP | disclosed |
| US-20190161501-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT | SHIONOGI & CO., LTD. (JP) | 2019-05-30 | — | — | US | disclosed |
| US-10221195-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-03-05 | — | — | US | disclosed |
| US-20180334461-A1 | NOVEL PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-22 | — | — | US | disclosed |
| US-10087149-B2 | Selective histone deacetylase 8 inhibitors | TRUSTEES OF BOSTON UNIVERSITY (US) | 2018-10-02 | — | — | US | disclosed |
| EP-2217602-B1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TREATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2018-08-29 | — | — | EP | disclosed |
| WO-2018119449-A1 | OXAZEPINE DERIVATIVES HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018119444-A1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-06-28 | — | — | WO | disclosed |
| US-9988373-B2 | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-20180141960-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-05-24 | — | — | US | disclosed |
| EP-3319970-A1 | PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS | Daiichi Sankyo Company, Limited (JP) | 2018-05-16 | — | — | EP | disclosed |
| US-20180118694-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| US-9920068-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-03-20 | — | — | US | disclosed |
| EP-3287443-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Shionogi & Co., Ltd (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-9890167-B2 | Pyrazine compounds for the treatment of infectious diseases | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9879032-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-01-30 | — | — | US | disclosed |
| EP-3245206-A1 | PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. Hoffmann-La Roche AG (CH) | 2017-11-22 | — | — | EP | disclosed |
| US-9758513-B2 | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20170240562-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-08-24 | — | — | US | disclosed |
| US-20170210755-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-07-27 | — | — | US | disclosed |
| WO-2017061534-A1 | DIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2017-04-13 | — | — | WO | disclosed |
| US-20170073337-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-03-16 | — | — | US | disclosed |
| EP-3129370-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2017-02-15 | — | — | EP | disclosed |
| CN-106414431-A | Dihydrothiazine and dihydrooxazine derivatives having BACE1 inhibitory activity | 盐野义制药株式会社 | 2017-02-15 | — | — | CN | disclosed |
| WO-2017007943-A1 | PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-01-12 | — | — | WO | disclosed |
| US-20170008881-A1 | DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2017-01-12 | — | — | US | disclosed |
| US-9540359-B2 | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2017-01-10 | — | — | US | disclosed |
| US-20160318916-A1 | NITROGEN-CONTAINING SIX-MEMBERED CYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2016-11-03 | — | — | US | disclosed |
| US-20160237090-A1 | NOVEL PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2016-08-18 | — | — | US | disclosed |
| WO-2016113273-A1 | PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-07-21 | — | — | WO | disclosed |
| US-20150352079-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-12-10 | — | — | US | disclosed |
| WO-2015156421-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-10-15 | — | — | WO | disclosed |
| US-20150266865-A1 | DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-09-24 | — | — | US | disclosed |
| EP-2912035-A1 | DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2015-09-02 | — | — | EP | disclosed |
| US-8822479-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8809348-B2 | 6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| WO-2014116962-A1 | SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2014-07-31 | — | — | WO | disclosed |
| US-8772277-B2 | Nitrogen-containing heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-08 | — | — | US | disclosed |
| WO-2014065434-A1 | DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2014-05-01 | — | — | WO | disclosed |
| US-8648085-B2 | 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-11 | — | — | US | disclosed |
| US-8642605-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| EP-2298773-B1 | 6-Cyclomethyl and 6-alkylmethyl substituted pyrazolopyrimidines | BOEHRINGER INGELHEIM INT (DE) | 2013-06-19 | — | — | EP | disclosed |
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20130072467-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2013-03-21 | — | — | US | disclosed |
| US-20130040951-A9 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2013-02-14 | — | — | US | disclosed |
| WO-2013018929-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-07 | — | — | WO | disclosed |
| EP-2530078-A1 | THIAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |
| US-8304557-B2 | Fused heterocycle derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20120196864-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2012-08-02 | — | — | US | disclosed |
| EP-2450352-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER | Takeda Pharmaceutical Company Limited (JP) | 2012-05-09 | — | — | EP | disclosed |
| US-20120010224-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN (DE) | 2012-01-12 | — | — | US | disclosed |
| US-8044060-B2 | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-25 | — | — | US | disclosed |
| EP-1626971-B1 | 6-CYCLYLMETHYL- AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2011-08-10 | — | — | EP | disclosed |
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2298773-A1 | 6-Cyclomethyl and 6-alkylmethyl substituted pyrazolopyrimidines | Boehringer Ingelheim International GmbH (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-20110065730-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN | 2011-03-17 | — | — | US | disclosed |
| US-20110046169-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-24 | — | — | US | disclosed |
| US-20110015193-A1 | 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MUDULATORS FOR THE TREATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-01-20 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
| US-7786079-B2 | Substituted nonadepsipeptides | AICURIS GMBH & CO. KG. (DE) | 2010-08-31 | — | — | US | disclosed |
| EP-2217602-A1 | 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2010-08-18 | — | — | EP | disclosed |
| EP-1628980-B1 | 6-ARYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2010-04-28 | — | — | EP | disclosed |
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| US-20100035900-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-1809653-B1 | SUBSTITUTED NONADEPSIPEPTIDES | AICURIS GMBH & CO KG (DE) | 2010-01-20 | — | — | EP | disclosed |
| US-20090286713-A9 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2009-11-19 | — | — | US | disclosed |
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |
| US-7615558-B2 | 6-arylmethylprazolo[3,4-d]pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-20090163488-A1 | FUSED HETEROCYCLE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-25 | — | — | US | disclosed |
| WO-2009068617-A1 | 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
| EP-1931706-A4 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | BIOTIE THERAPIES CORP (FI) | 2009-05-27 | — | — | EP | disclosed |
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |
| US-20090023735-A1 | Sulphonamide Derivatives | BIOTIE THERAPIES CORP. (FI) | 2009-01-22 | — | — | US | disclosed |
| US-20090023735-A1 | Sulphonamide Derivatives | BIOTIE THERAPIES CORP. (FI) | 2009-01-22 | — | — | US | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |
| US-20080255028-A1 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-16 | — | — | US | disclosed |
| CN-101268041-A | Sulphonamide derivatives | BIOTIE THERAPIES CORP (FI) | 2008-09-17 | — | — | CN | disclosed |
| EP-1931706-A1 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | Biotie Therapies Corp. (FI) | 2008-06-18 | — | — | EP | disclosed |
| EP-1924554-A1 | SULPHONAMIDE DERIVATIVES | Biotie Therapies Corp. (FI) | 2008-05-28 | — | — | EP | disclosed |
| EP-1924554-A1 | SULPHONAMIDE DERIVATIVES | Biotie Therapies Corp. (FI) | 2008-05-28 | — | — | EP | disclosed |
| US-20080058251-A1 | Substituted nonadepsipeptides | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | disclosed |
| EP-1888076-A1 | USE OF PYRAZOLOPYRIMIDINE AGAINST CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-02-20 | — | — | EP | disclosed |
| EP-1809653-A1 | SUBSTITUTED NONADEPSIPEPTIDES | AiCuris GmbH & Co. KG (DE) | 2007-07-25 | — | — | EP | disclosed |
| US-20070161662-A1 | 6-Arylmethyl-substituted pyrazolopyrimidines | BAYER HEALTHCARE AG (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070105876-A1 | 6-Cyclylmethyl- and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| WO-2007034035-A1 | SULPHONAMIDE DERIVATIVES | BIOTIE THERAPIES CORPORATION (FI) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007034035-A1 | SULPHONAMIDE DERIVATIVES | BIOTIE THERAPIES CORPORATION (FI) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007031608-A1 | COLLAGEN RECEPTOR I-DOMAIN BINDING MODULATORS | BIOTIE THERAPIES CORPORATION (FI) | 2007-03-22 | — | — | WO | disclosed |
| US-20070037807-A1 | Pyridine compounds as inhibitors of dipeptidyl peptidase IV | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | US | disclosed |
| WO-2006125548-A1 | USE OF PYRAZOLOPYRIMIDINE AGAINST CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2006-11-30 | — | — | WO | disclosed |
| EP-1678138-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | Takeda Pharmaceutical Company Limited (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2006042654-A1 | SUBSTITUTED NONADEPSIPEPTIDES | AICURIS GMBH & CO. KG (DE) | 2006-04-27 | — | — | WO | disclosed |
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1628980-A1 | 6-ARYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | Bayer HealthCare AG (DE) | 2006-03-01 | — | — | EP | disclosed |
| EP-1626971-A1 | 6-CYCLYLMETHYL- AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | Bayer HealthCare AG (DE) | 2006-02-22 | — | — | EP | disclosed |
| WO-2005042488-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | WO | disclosed |
| EP-1507757-A1 | LACTAMS USED AS ANTI-VIRAL AGENTS | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2004099210-A1 | 6-ARYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004099211-A1 | 6-CYCLYLMETHYL- AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2004-11-18 | — | — | WO | disclosed |
| EP-0807105-B1 | PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-06-16 | — | — | EP | disclosed |
| EP-1063235-B1 | BENZOFURYLPYRONE DERIVATIVES | TEIJIN LTD (JP) | 2004-05-12 | — | — | EP | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| WO-2003097595-A1 | LACTAMS USED AS ANTI-VIRAL AGENTS | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |
| US-20030186976-A1 | Benzofurylpyrone derivatives | TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION | 2003-10-02 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6589984-B1 | Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as | TEIJIN LIMITED (JP) | 2003-07-08 | — | — | US | disclosed |
| EP-1063235-A1 | BENZOFURYLPYRONE DERIVATIVES | TEIJIN LIMITED (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| US-5994368-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| EP-0807105-A1 | PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-19 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |
| WO-1996013485-A1 | PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-09 | — | — | WO | disclosed |
| US-5051346-A | Silver halide emulsion containing a coupler dispersed in oil droplets and another in an alkali aqueous solution; color films; improved photosensitivity, graininess, sharpness, reproduction | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1991-09-24 | — | — | US | disclosed |
| EP-0192199-B1 | LIGHT-SENSITIVE PHOTOGRAPHIC MATERIAL | KONICA CORPORATION (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4975359-A | Photographic light-sensitive materials containing couplers that release diffusible dyes and DIR compounds | FUJI PHOTO FILM CO., LTD. (JP) | 1990-12-04 | — | — | US | disclosed |
| EP-0115303-B1 | SILVER HALIDE COLOUR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |
| EP-0174871-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL | KONICA CORPORATION (JP) | 1989-04-19 | — | — | EP | disclosed |
| EP-0114674-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |
| US-4789624-A | HIGH SPEED COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1988-12-06 | — | — | US | disclosed |
| EP-0115305-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1988-06-15 | — | — | EP | disclosed |
| US-4729944-A | NONDIFFUSIBLE COUPLER, IMPROVED GRANINESS AND SENSITIVITY | FUJI PHOTO FILM CO., LTD. (JP) | 1988-03-08 | — | — | US | disclosed |
| EP-0096873-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIALS | FUJI PHOTO FILM CO., LTD. (JP) | 1987-12-02 | — | — | EP | disclosed |
| US-4705743-A | NONDIFFUSING COUPLER | FUJI PHOTO FILM CO. LTD. (JP) | 1987-11-10 | — | — | US | disclosed |
| US-4701404-A | PLURALITY OF SUBBING LAYERS HAVING DIFFERENT SENSITIVITY | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1987-10-20 | — | — | US | disclosed |
| EP-0024033-B1 | PHOTOGRAPHIC COLOUR COUPLERS AND LIGHT-SENSITIVE MATERIAL CONTAINING THEM | FUJI PHOTO FILM CO., LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |
| EP-0192199-A2 | Light-sensitive photographic material | KONICA CORPORATION (JP) | 1986-08-27 | — | — | EP | disclosed |
| US-4578346-A | POLYMERIC AND NON-POLYMERIC COUPLERS | FUJI PHOTO FILM CO., LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0174871-A2 | Silver halide color photographic material | KONICA CORPORATION (JP) | 1986-03-19 | — | — | EP | disclosed |
| US-4567135-A | DIFFUSION TRANSFER, COUPLERS OF DIFFERENT REACTION SPEEDS | FUJI PHOTO FILM CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4536472-A | IMPROVED GRANULARITY AND VISUAL SENSATION OF GRAININESS | FUJI PHOTO FILM CO., LTD. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4489155-A | COLORLESS COMPETING COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1984-12-18 | — | — | US | disclosed |
| US-4476219-A | GALLIC AMIDE DERIVATIVE, HIGH SPEED REACTION COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1984-10-09 | — | — | US | disclosed |
| EP-0115303-A2 | Silver halide colour photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |
| EP-0115305-A2 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |
| EP-0114674-A2 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1984-08-01 | — | — | EP | disclosed |
| EP-0096873-A2 | Silver halide color photographic light-sensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1983-12-28 | — | — | EP | disclosed |
| US-4345025-A | CYAN DYE, COUPLERS | FUJI PHOTO FILM CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| US-4296199-A | CONTAINING A CYAN COLOR FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1981-10-20 | — | — | US | disclosed |
| US-4296200-A | CONTAINING A COLORLESS CYAN COLOR FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1981-10-20 | — | — | US | disclosed |
| US-4294918-A | CONTAINING A COLORLESS CYAN COLOR FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1981-10-13 | — | — | US | disclosed |
| US-4283486-A | DISCOLORATION INHIBITION | FUJI PHOTO FILM CO., LTD. (JP) | 1981-08-11 | — | — | US | disclosed |
| US-4264722-A | A COLORLESS CYAN-COLOR-FORMING COUPLER COMPRISING 4-OXY-DERIVATIVES OF 1-HYDROXY-2-SEC-AMIDO-NAPHTHALENE OR BENZENE | FUJI PHOTO FILM CO., LTD. (JP) | 1981-04-28 | — | — | US | disclosed |
| US-4254212-A | ALKOXY SUBSTITUTED SULFONYL | FUJI PHOTO FILM CO., LTD. (JP) | 1981-03-03 | — | — | US | disclosed |
| EP-0024033-A1 | Photographic colour couplers and light-sensitive material containing them | FUJI PHOTO FILM CO., LTD. (JP) | 1981-02-18 | — | — | EP | disclosed |
| US-4228233-A | CYAN DYE FORMING, COLORLESS COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1980-10-14 | — | — | US | disclosed |
| US-4217410-A | CYAN DYE COUPLER, PHOSPHATE SOLVENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1980-08-12 | — | — | US | disclosed |
| US-4083721-A | AROMATIC PRIMARY AMINE DEVELOPER | FUJI PHOTO FILM CO., LTD. (JA) | 1978-04-11 | — | — | US | disclosed |
| US-4072525-A | COLOR PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JA) | 1978-02-07 | — | — | US | disclosed |
| US-4032345-A | SILVER HALIDE MATERIALS CONTAINING PHOTOGRAPHIC COLOR COUPLERS WITH ISOTHIOCYANATO GROUPS | FUJI PHOTO FILM CO., LTD. (JA) | 1977-06-28 | — | — | US | disclosed |
| US-4032345-A | SILVER HALIDE MATERIALS CONTAINING PHOTOGRAPHIC COLOR COUPLERS WITH ISOTHIOCYANATO GROUPS | FUJI PHOTO FILM CO., LTD. (JA) | 1977-06-28 | — | — | US | disclosed |