Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | DRD2 | P14416 | 2/20 | 0.70 |
| ▸ | HTR2C | P28335 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.70 |
| ▸ | HTR1D | P28221 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673587 | 0.95 | HTR2A (0.63) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL9671506 | 0.93 | HTR2A (0.70) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL9671867 | 0.92 | HTR2A (0.71) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL11007280 | 0.88 | HTR2A (0.81) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL9670899 | 0.87 | HTR2A (0.64) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL10734984 | 0.86 | ADRA1B (0.55) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL3894977 | 0.85 | HTR2A (0.76) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL11009545 | 0.84 | HTR2A (0.72) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| SCHEMBL10742828 | 0.84 | HTR2A (0.72) | HTR2ACYP3A4HPGDALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10737791 | 0.84 | HTR2A (0.75) | HTR2ACYP3A4HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184258-B1 | NOVEL DERIVATIVES OF HYDROXY- OR AMINO-SUBSTITUTED (PIPERIDINYLALKYL)QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0184258-A2 | Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-06-11 | — | — | EP | disclosed |