⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbon Tetrachloride SCHEMBL966839 | 1.00 | — | — | |
| Acetonitrile SCHEMBL28029152 | 0.89 | — | — | |
| Trichloroethane SCHEMBL1366178 | 0.86 | — | — | |
| Acetonitrile SCHEMBL29833514 | 0.84 | — | — | |
| Acetonitrile SCHEMBL27544945 | 0.82 | — | — | |
| Carbon Tetrachloride SCHEMBL10760664 | 0.82 | LMNA (0.40) | — | |
| Acetonitrile SCHEMBL1330624 | 0.78 | — | — | |
| Acetonitrile SCHEMBL6693864 | 0.78 | — | — | |
| Acetonitrile SCHEMBL1331294 | 0.78 | — | — | |
| Acetonitrile SCHEMBL1330705 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158367-A1 | TRICYCLIC COMPOUND AS HIF2-ALPHA INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD (CN) | 2024-05-16 | — | — | US | disclosed |
| EP-4299570-A1 | TRICYCLIC COMPOUND AS HIF2A INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2024-01-03 | — | — | EP | disclosed |
| CN-116724035-A | Tri-fused ring compounds as HIF2 alpha inhibitors, and preparation method and application thereof | 上海济煜医药科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| US-11319300-B2 | Polyfluoro-substituted aromatic heterocyclic derivative, pharmaceutical composition containing same, and applications thereof | GUANGZHOU LIXIN PHARMACEUTICAL CO., LTD. (CN) | 2022-05-03 | — | — | US | disclosed |
| CN-114206864-A | Quinazoline-2, 4-dione derivatives as PARP inhibitors | 苏州四体康宸医药科技有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-108872106-B | Method for measuring trace sulfite in water body | 电子科技大学 | 2021-03-19 | — | — | CN | disclosed |
| US-20200165229-A1 | POLYFLUORO-SUBSTITUTED AROMATIC HETEROCYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND APPLICATIONS THEREOF | GUANGZHOU LIXIN PHARMACEUTICAL CO., LTD. (CN) | 2020-05-28 | — | — | US | disclosed |
| US-10577359-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2020-03-03 | — | — | US | disclosed |
| EP-1809301-B1 | 2-FLUORO-2-ALKYL-SUBSTITUTED D-RIBONOLACTONE INTERMEDIATES | GILEAD PHARMASSET LLC (US) | 2019-11-06 | — | — | EP | disclosed |
| CN-110337428-A | The method for being used to prepare fluoro-alkyl nitrile and corresponding fluoro-alkyl tetrazolium | 拜耳作物科学股份公司 | 2019-10-15 | — | — | CN | disclosed |
| EP-0497673-B1 | Medical material, method for production thereof, and medical apparatus | TERUMO CORP (JP) | 1997-03-26 | — | — | EP | disclosed |
| US-5599922-A | INHIBITOR TO SNAKE VENON PHOSPHODIESTERASE | LYNX THERAPEUTICS, INC. (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0754242-A1 | OLIGONUCLEOTIDE N3'$m(7)P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES | LYNX THERAPEUTICS, INC. (US) | 1997-01-22 | — | — | EP | disclosed |
| EP-0753315-A2 | Medical material, method for production thereof, and medical apparatus | TERUMO KABUSHIKI KAISHA (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5591607-A | Oligonucleotide N3→P5' phosphoramidates: triplex DNA formation | LYNX THERAPEUTICS, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5489303-A | BOUND TO THE SURFACE OF POLYMERIC SUBSTRATE VIA A COPOLYMER CONTAINING EPOXY, CARBOXY, CARBOXYESTER, ALCOHOL AND ALDEHYDE REACTIVE GROUPS | TERUMO KABUSHIKI KAISHA (JP) | 1996-02-06 | — | — | US | disclosed |
| WO-1995025814-A1 | OLIGONUCLEOTIDE N3'→P5' PHOSPHORAMIDATES: SYNTHESIS AND COMPOUNDS; HYBRIDIZATION AND NUCLEASE RESISTANCE PROPERTIES | LYNX THERAPEUTICS, INC. (US) | 1995-09-28 | — | — | WO | disclosed |
| EP-0509753-A1 | Semi-synthetic immunosuppressive macrolides | MERCK & CO. INC. (US) | 1992-10-21 | — | — | EP | disclosed |
| US-5147877-A | Autoimmune and skin disorders, organ transplant | MERCK & CO. INC. (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0497673-A1 | Medical material, method for production thereof, and medical apparatus | TERUMO KABUSHIKI KAISHA (JP) | 1992-08-05 | — | — | EP | disclosed |