Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680557 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL9672977 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL10677970 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL10676222 | 0.99 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL9674431 | 0.99 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL10681970 | 0.95 | MEN1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL10681979 | 0.95 | MEN1 (0.51) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL9673762 | 0.90 | MEN1 (0.60) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL10676530 | 0.90 | MEN1 (0.60) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 | |
| SCHEMBL23727144 | 0.83 | HPGD (0.57) | ALDH1A1SMN1; SMN2LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250725-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1992-11-04 | — | — | EP | disclosed |
| US-4757080-A | Pharmaceuticals | HEUMANN PHARMA GMBH & CO. (DE) | 1988-07-12 | — | — | US | disclosed |
| EP-0250725-A1 | 1,4-Dihydropyridine derivatives, processes for their preparation and medicaments containing them | HEUMANN PHARMA GMBH & CO (DE) | 1988-01-07 | — | — | EP | disclosed |