Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18857699 | 0.86 | EPHX1 (0.46) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL697518 | 0.84 | — | — | |
| SCHEMBL305952 | 0.79 | EPHX1 (0.43) | EPHX1 | |
| SCHEMBL698654 | 0.79 | — | — | |
| SCHEMBL2334130 | 0.78 | EPHX1 (0.40) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL8582703 | 0.77 | EPHX1 (0.47) | EPHX1 | |
| SCHEMBL10598876 | 0.77 | EPHX1 (0.47) | EPHX1 | |
| SCHEMBL72976 | 0.77 | EPHX1 (0.47) | EPHX1 | |
| Hydrochloric Acid SCHEMBL5209870 | 0.77 | EPHX1 (0.39) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL9345682 | 0.77 | GABRA1 (0.44) | GABRA1TSHRGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112603-B2 | APHIDICOLANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-18 | — | — | EP | claimed |
| EP-0112603-B1 | APHIDICOLANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-03-04 | — | — | EP | claimed |
| EP-0112603-A1 | Aphidicolane derivatives, their preparation and pharmaceutical compositions comprising them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-07-04 | — | — | EP | claimed |
| EP-0112603-B2 | APHIDICOLANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-18 | — | — | EP | disclosed |
| US-5039710-A | Homocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-08-13 | — | — | US | disclosed |
| US-4803201-A | Homocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0112603-B1 | APHIDICOLANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-03-04 | — | — | EP | disclosed |
| EP-0112603-A1 | Aphidicolane derivatives, their preparation and pharmaceutical compositions comprising them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-07-04 | — | — | EP | disclosed |