Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711979 | 0.82 | ERCC5 (0.49) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1712729 | 0.80 | TDP1 (0.47) | TDP1L3MBTL1MEN1NPC1KMT2A | |
| SCHEMBL18192832 | 0.79 | ALDH1A1 (0.40) | TDP1L3MBTL1CTDSP1ALDH1A1KDM4E | |
| SCHEMBL18192830 | 0.79 | ALDH1A1 (0.40) | TDP1L3MBTL1CTDSP1ALDH1A1KDM4E | |
| SCHEMBL31688807 | 0.78 | KDM4E (0.55) | TDP1L3MBTL1CTDSP1ALDH1A1KDM4E | |
| SCHEMBL4428838 | 0.78 | KDM4E (0.55) | TDP1L3MBTL1CTDSP1ALDH1A1KDM4E | |
| SCHEMBL18192844 | 0.78 | CTDSP1 (0.33) | TDP1L3MBTL1CTDSP1NPC1KDM4E | |
| SCHEMBL7626205 | 0.77 | RXFP1 (0.51) | TDP1L3MBTL1MEN1NPC1KMT2A | |
| SCHEMBL18192896 | 0.77 | KDM4E (0.37) | NPC1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL12647390 | 0.76 | MEN1 (0.51) | TDP1L3MBTL1CTDSP1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | BACE1, BACE2, APP | TDP1 279/4885L3MBTL1 3403/4885CTDSP1 1830/4885 |
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | TDP1 279/4885L3MBTL1 3403/4885CTDSP1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.