Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 9/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.60 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | THPO | P40225 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677428 | 0.94 | CACNA1F (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL10893329 | 0.85 | CACNA1C (0.69) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL11819347 | 0.85 | CACNA1F (0.72) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL9511512 | 0.84 | CACNA1F (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL11774845 | 0.83 | CACNA1F (0.60) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL10745168 | 0.82 | CACNA1C (0.70) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL11778951 | 0.82 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL9513433 | 0.81 | CACNA1F (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL9505389 | 0.81 | CACNA1F (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CACHE | |
| SCHEMBL10861491 | 0.81 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255075-B1 | 2-(ACYLTHIO)METHYL DIHYDROPYRIDINES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-30 | — | — | EP | disclosed |
| US-4935433-A | 2-(acylthio)methyl dihydropyridines, and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1990-06-19 | — | — | US | disclosed |
| EP-0255075-A1 | 2-(acylthio)methyl dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-02-03 | — | — | EP | disclosed |