Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263139 | 1.00 | DRD2 (0.53) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| SCHEMBL6260666 | 0.89 | DRD2 (0.56) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| SCHEMBL6260664 | 0.89 | DRD2 (0.56) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL6264103 | 0.88 | DRD2 (0.55) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL9676050 | 0.88 | DRD2 (0.55) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| SCHEMBL6266691 | 0.85 | LARS1 (0.52) | DRD2DRD3HDAC1SMN1; SMN2LARS1 | |
| SCHEMBL9677794 | 0.85 | LARS1 (0.52) | DRD2DRD3HDAC1SMN1; SMN2LARS1 | |
| SCHEMBL9678341 | 0.80 | DRD2 (0.62) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| SCHEMBL7835172 | 0.78 | HDAC1 (0.63) | DRD2DRD3HDAC1CYP11B2CYP11B1 | |
| SCHEMBL9676839 | 0.76 | SMN1; SMN2 (0.50) | DRD2DRD3HDAC1CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268229-B1 | IMIDAZOLIDINONE COMPOUNDS, PROCESSES FOR PREPARATION THEREOF, COMPOSITIONS COMPRISING SUCH COMPOUNDS, AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS HAVING THERAPEUTIC VALUE | TANABE SEIYAKU CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |
| US-4886817-A | Imidazolidinones as brain activators | TANABE SEIYAKU CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |