Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | RHEB | Q15382 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 5/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14859468 | 0.84 | NPC1 (0.52) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL14859469 | 0.84 | NPC1 (0.52) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL14669464 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL9385123 | 0.80 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| Hydrochloric Acid SCHEMBL9703454 | 0.79 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL9678715 | 0.79 | MAPT (0.60) | KDM4EALDH1A1HPGDCYP3A4HSD17B10 | |
| SCHEMBL9379605 | 0.79 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL9677328 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL9679534 | 0.78 | NPC1 (0.67) | KDM4EALDH1A1HPGDRHEBCYP1A2 | |
| SCHEMBL9378150 | 0.76 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDRHEBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207483-B1 | BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |