Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444379 | 0.84 | CCR3 (0.49) | HTR2AALDH1A1 | |
| SCHEMBL9676471 | 0.83 | ALDH1A1 (0.44) | KCNH2NAMPTALDH1A1HRH3CYP3A4 | |
| SCHEMBL9447542 | 0.83 | ALDH1A1 (0.45) | KCNH2NAMPTALDH1A1HRH3CYP3A4 | |
| SCHEMBL9444455 | 0.82 | KCNH2 (0.65) | KCNH2HTR2AHTR2CNAMPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL9444345 | 0.81 | KCNH2 (0.65) | KCNH2HTR2AHTR2CNAMPTALDH1A1 | |
| SCHEMBL9444499 | 0.79 | KCNH2 (0.58) | KCNH2HTR2AHTR2CNAMPTALDH1A1 | |
| SCHEMBL9678360 | 0.78 | KCNH2 (0.69) | KCNH2HTR2AHTR2CNAMPTCYP3A4 | |
| SCHEMBL9678100 | 0.77 | KCNH2 (0.48) | KCNH2HTR2AHTR2CALDH1A1 | |
| SCHEMBL9444439 | 0.77 | KCNH2 (0.60) | KCNH2HTR2ANAMPTALDH1A1CYP3A4 | |
| SCHEMBL9444290 | 0.76 | KCNH2 (0.59) | KCNH2HTR2ANAMPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304888-B1 | SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME | Eisai Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-5162347-A | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0304888-A1 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same | Eisai Co., Ltd. (JP) | 1989-03-01 | — | — | EP | disclosed |