Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TLR3 | O15455 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678200 | 0.94 | DYRK1A (0.59) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL9679546 | 0.87 | KIT (0.53) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL24277810 | 0.85 | KIT (0.61) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL8548801 | 0.83 | KIT (0.54) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL13356168 | 0.80 | KIT (0.67) | KITDYRK1ABCHEKDM4EMEN1 | |
| Dimethylamine SCHEMBL8547837 | 0.80 | KIT (0.54) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL24277001 | 0.80 | KIT (0.57) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL29445100 | 0.79 | KDM4E (0.58) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL9090021 | 0.79 | KDM4E (0.58) | KITDYRK1ABCHEKDM4EMEN1 | |
| SCHEMBL612838 | 0.79 | KIT (0.59) | KITDYRK1ABCHEKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416024-A4 | SUBSTITUTED 6H-PYRIDO (4,3-B) CARBAZOLES | — | 1992-04-15 | — | — | EP | disclosed |
| EP-0416024-A1 | SUBSTITUTED 6H-PYRIDO (4,3-b) CARBAZOLES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989011480-A1 | SUBSTITUTED 6H-PYRIDO (4,3-b) CARBAZOLES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1989-11-30 | — | — | WO | disclosed |