Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680615 | 0.94 | HPGD (0.58) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL7168025 | 0.90 | RXRA (0.62) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL30102546 | 0.90 | RXRA (0.62) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL2343079 | 0.88 | MAOB (0.59) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL28903575 | 0.87 | HPGD (0.66) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL30102538 | 0.87 | HPGD (0.66) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL11762649 | 0.87 | RXRA (0.61) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL15673277 | 0.84 | RXRA (0.62) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL31025721 | 0.84 | NPC1 (0.75) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL11345190 | 0.84 | GLRA1 (0.60) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012981-A1 | SUBSTITUTED PHENYL-1,3 DIOXOLOQUINOLINE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | GLAXO INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496634-A1 | Substituted phenyl-1,3-dioxoloquinoline derivatives and their use as antitumor agents | GLAXO INC. (US) | 1992-07-29 | — | — | EP | disclosed |
| US-5126351-A | Inhibitors of topoisomerase | GLAXO INC. (US) | 1992-06-30 | — | — | US | disclosed |