SCHEMBL9680243

SCHEMBL9680243

CCCCCCCCCCCCCCCCCCCCCCC(Cl)C(=O)Cl

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 7/20 0.48
FFAR1 O14842 2/20 0.48
ALDH1A1 P00352 1/20 0.48
TSHR P16473 1/20 0.48
MAPT P10636 1/20 0.47
LCK P06239 1/20 0.47
PPARD Q03181 1/20 0.47
ZDHHC20 Q5W0Z9 1/20 0.47
ZDHHC2 Q9UIJ5 1/20 0.47
CA2 P00918 1/20 0.45
FFAR4 Q5NUL3 1/20 0.44
ACE2 Q9BYF1 1/20 0.44
FDPS P14324 3/20 0.43
CA1 P00915 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6852786 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL5165195 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL5981684 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL11174743 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL11198382 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL10343401 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL5337014 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL28597286 1.00 GPR84 (0.48) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL8868526 0.98 GPR84 (0.45) GPR84FFAR1ALDH1A1TSHRMAPT
SCHEMBL7289166 0.91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5116830-A Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses SRI INTERNATIONAL (US) 1992-05-26 US disclosed
EP-0190149-B1 STEREOISOMETRICALLY PURE 17-ALPHA-ETHYNYL-ESTRA-2-EN-17BETA-OL AND ESTERS THEREOF SRI INTERNATIONAL (US) 1989-12-13 EP disclosed
US-4788218-A MALE FERTILITY CONTROL SRI INTERNATIONAL (US) 1988-11-29 US disclosed
EP-0190149-A1 STEREOISOMETRICALLY PURE 17-ALPHA-ETHYNYL-ESTRA-2-EN-17BETA-OL AND ESTERS THEREOF. STANFORD RES INST INT (US) 1986-08-13 EP disclosed
EP-0182808-A1 17 a?$g(b)-HYDROXY-7$g(a)-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES SRI INTERNATIONAL (US) 1986-06-04 EP disclosed
WO-1986001208-A1 STEREOISOMETRICALLY PURE 17-ALPHA-ETHYNYL-ESTRA-2-EN-17BETA-OL AND ESTERS THEREOF SRI INTERNATIONAL (US) 1986-02-27 WO disclosed
WO-1985005361-A1 17abeta-HYDROXY-7alpha-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES SRI INTERNATIONAL (US) 1985-12-05 WO disclosed