Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9476064 | 0.98 | BRD4 (0.55) | BRD4GAANPC1POLBPDE3B | |
| SCHEMBL9477063 | 0.80 | GAA (0.55) | BRD4GAANPC1POLBPDE3B | |
| SCHEMBL9475536 | 0.79 | GAA (0.57) | BRD4GAANPC1POLBKDM4E | |
| SCHEMBL9475977 | 0.77 | KDM4E (0.67) | BRD4GAANPC1POLBKDM4E | |
| SCHEMBL10675219 | 0.76 | MAPT (0.54) | BRD4GAAPOLBPDE3BPDE3A | |
| SCHEMBL4514368 | 0.73 | KDM4E (0.50) | GAANPC1POLBPDE3BPDE3A | |
| SCHEMBL18044655 | 0.73 | GAA (0.62) | BRD4GAANPC1POLBPDE3B | |
| SCHEMBL9846132 | 0.73 | PDE3B (0.53) | GAAPDE3BPDE3APDE4APDE4B | |
| SCHEMBL3678604 | 0.73 | BRD4 (0.47) | BRD4GAANPC1POLBKDM4E | |
| SCHEMBL13995853 | 0.72 | GAA (0.71) | BRD4GAANPC1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568751-A | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-04 | — | — | US | claimed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |