Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.52 |
| ▸ | ATF4 | P18848 | 3/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667235 | 0.85 | PARP15 (0.55) | PARP15PARP10PARP2ATF4LTA4H | |
| SCHEMBL10207302 | 0.82 | PARP15 (0.51) | PARP15PARP10PARP2CYP4F2CYP4A11 | |
| SCHEMBL765066 | 0.82 | PARP15 (0.51) | PARP15PARP10PARP2CYP4F2CYP4A11 | |
| SCHEMBL10203545 | 0.79 | ACACB (0.59) | PARP15PARP10PARP2CYP4F2CYP4A11 | |
| SCHEMBL879115 | 0.79 | ACACB (0.59) | PARP15PARP10PARP2CYP4F2CYP4A11 | |
| SCHEMBL4186691 | 0.76 | PARP15 (0.58) | PARP15PARP10PARP2LTA4H | |
| SCHEMBL29082785 | 0.76 | ATF4 (0.84) | ATF4 | |
| SCHEMBL21413242 | 0.76 | CYP4F2 (0.47) | PARP15PARP10PARP2CYP4F2CYP4A11 | |
| SCHEMBL29024848 | 0.75 | PARP15 (0.64) | PARP15PARP10PARP2 | |
| SCHEMBL416244 | 0.75 | PARP15 (0.72) | PARP15PARP10PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175319-A | Antiprotozoa agent, useful for treating malaria, theileriosis, coccidiosis and prophylaxix | BURROUGHS WELLCOME CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5053432-A | Antiprotozoa agents; treatment of malaria | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123238-B1 | NAPHTHOQUINONE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-06-10 | — | — | EP | disclosed |
| EP-0123238-A2 | Naphthoquinone derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |