Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923932 | 0.82 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL15043630 | 0.76 | GRIN1 (0.52) | HDAC4S1PR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8861291 | 0.76 | BACE1 (0.41) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL435025 | 0.73 | GRIN2D (0.43) | HDAC4S1PR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11605620 | 0.72 | GRIN2D (0.49) | S1PR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL435389 | 0.72 | HTT (0.43) | HDAC4S1PR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10178152 | 0.72 | GRIN1 (0.46) | HDAC4S1PR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6294302 | 0.72 | DPP4 (0.50) | HDAC4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11377939 | 0.72 | GRIN1 (0.63) | HDAC4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7241011 | 0.72 | ALDH1A1 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118697-A | Acyl-coenzyme A: cholesterol acyltransferase inhibitors for reducing blood cholesterol levels | WARNER-LAMBERT COMPANY (US) | 1992-06-02 | — | — | US | disclosed |