Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680966 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1PKMTAAR1 | |
| SCHEMBL9679926 | 0.85 | ALDH1A1 (0.36) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| SCHEMBL9679933 | 0.85 | ALDH1A1 (0.36) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| Dimethylcarbate SCHEMBL9679440 | 0.83 | ALDH1A1 (0.37) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| Dimethylcarbate SCHEMBL9679433 | 0.83 | ALDH1A1 (0.37) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| SCHEMBL9017850 | 0.82 | ALDH1A1 (0.35) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| SCHEMBL9017856 | 0.82 | ALDH1A1 (0.35) | SMN1; SMN2RAB9ANPC1NPSR1HTT | |
| SCHEMBL9679510 | 0.81 | KDM5A (0.34) | SMN1; SMN2RAB9ANPC1PKMNPSR1 | |
| SCHEMBL9679504 | 0.81 | KDM5A (0.34) | SMN1; SMN2RAB9ANPC1PKMNPSR1 | |
| SCHEMBL9017842 | 0.80 | HSP90AA1 (0.42) | SMN1; SMN2RAB9ANPC1PKMTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |