SCHEMBL9681107

SCHEMBL9681107

Fc1ccc(F)c(-c2ccno2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.47
NOTUM Q6P988 1/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
SLC9A1 P19634 3/20 0.39
CYP1A2 P05177 1/20 0.38
CYP19A1 P11511 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
AR P10275 1/20 0.36
CA3 P07451 1/20 0.35
CA6 P23280 1/20 0.35
CA5A P35218 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
CA5B Q9Y2D0 1/20 0.35
S1PR2 O95136 1/20 0.35
S1PR4 O95977 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9680952 0.84 EPHX2 (0.43) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL29541717 0.84 EPHX2 (0.43) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL4053851 0.81 EPHX2 (0.67) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL4948481 0.81 SMN1; SMN2 (0.47) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL29541546 0.75 CYP1A2 (0.47) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL6817772 0.75 CYP1A2 (0.47) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL29542034 0.73 EPHX2 (0.44) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL9766850 0.72 CA9 (0.52) ALDH1A1SLC9A1CYP1A2CA3CA6
SCHEMBL29541410 0.71 NOTUM (0.41) EPHX2NOTUMKDM4EALDH1A1GAA
SCHEMBL9679859 0.70 NOTUM (0.65) EPHX2NOTUMKDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0486782-A1 Improved process for the synthesis of alpha-((dialkylamino)substituted-methylene)-beta-oxo-(substituted) propanenitriles AMERICAN CYANAMID COMPANY (US) 1992-05-27 EP claimed
US-5103015-A 5-(substituted)isoxazole compounds AMERICAN CYANAMID COMPANY (US) 1992-04-07 US claimed