Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.39 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL9839934 | 1.00 | GSR (0.43) | GSRSLC7A5PTGS1SLC7A11CPB2 | |
| Lysine SCHEMBL9679966 | 0.97 | GSR (0.41) | GSRSLC7A5PTGS1SLC7A11CPB2 | |
| Lysine SCHEMBL10862298 | 0.96 | GSR (0.48) | GSRSLC7A5PTGS1SLC7A11CPB2 | |
| Lysine SCHEMBL10862827 | 0.96 | GSR (0.48) | GSRSLC7A5PTGS1SLC7A11CPB2 | |
| Lysine SCHEMBL10346711 | 0.90 | GSR (0.54) | GSRSLC7A5SLC1A2SLC1A3THRB | |
| Lysine SCHEMBL28444584 | 0.90 | GSR (0.54) | GSRSLC7A5PTGS1SLC7A11CPB2 | |
| Lysine SCHEMBL9598249 | 0.90 | GSR (0.54) | GSRSLC7A5SLC1A2SLC1A3THRB | |
| Lysine SCHEMBL9598281 | 0.90 | GSR (0.54) | GSRSLC7A5SLC1A2SLC1A3THRB | |
| Lysine SCHEMBL10428792 | 0.89 | GSR (0.56) | GSRSLC7A5SLC1A2SLC1A3THRB | |
| Lysine SCHEMBL10428794 | 0.89 | GSR (0.56) | GSRSLC7A5SLC1A2SLC1A3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112737-A | Binding proteins | APPLIED BIOTECHNOLOGY, INC. (US) | 1992-05-12 | — | — | US | disclosed |