SCHEMBL9681852

SCHEMBL9681852

O=C(Oc1ccc2c(c1)C(=O)OC2=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.52
MAOA P21397 2/20 0.43
MAOB P27338 2/20 0.43
KMT2A Q03164 5/20 0.41
MEN1 O00255 3/20 0.41
HSD17B10 Q99714 1/20 0.41
TSHR P16473 1/20 0.40
GRM5 P41594 1/20 0.40
PTGES O14684 2/20 0.39
CA12 O43570 2/20 0.39
CA9 Q16790 2/20 0.39
CA2 P00918 2/20 0.39
CA1 P00915 1/20 0.39
CA7 P43166 1/20 0.39
NPC1 O15118 1/20 0.38
HTT P42858 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31124079 0.88 KMT2A (0.47) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL4598444 0.88 KMT2A (0.47) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL31124167 0.88 KMT2A (0.47) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL29426396 0.87 KMT2A (0.51) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL4204276 0.87 KMT2A (0.51) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL9681102 0.86 MAPT (0.60) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL4990373 0.84 KMT2A (0.49) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL29363037 0.84 CA2 (0.47) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL30693355 0.84 CA2 (0.47) MAPTMAOAMAOBKMT2AMEN1
SCHEMBL1608672 0.84 CA2 (0.47) MAPTMAOAMAOBKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5153335-A Reacting halophthalic anhydride and alkali metal salt with acid or acid derivative catalyst OCCIDENTAL CHEMICAL CORPORATION (US) 1992-10-06 US claimed
EP-0460687-A2 Process for the preparation of oxydiphthalic anhydride and acyloxyphthalic anhydrides OCCIDENTAL CHEMICAL CORPORATION (US) 1991-12-11 EP claimed