Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971805 | 0.78 | HTT (0.46) | MAPTCYP1A2CYP2D6KMT2ACYP2C19 | |
| SCHEMBL24196425 | 0.77 | CRHBP (0.49) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL969606 | 0.77 | CYP1A2 (0.52) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL2416637 | 0.75 | SMPD3 (0.47) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL25528727 | 0.74 | CYP2C19 (0.47) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| Hydrochloric Acid SCHEMBL6336950 | 0.74 | SMPD3 (0.46) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL5765855 | 0.73 | MAPK1 (0.50) | MAPTKMT2AMEN1POLBPIK3CA | |
| SCHEMBL973175 | 0.73 | KCNQ3 (0.51) | MAPTKMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30824626 | 0.73 | KCNQ3 (0.51) | MAPTKMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL15938813 | 0.73 | CYP2C19 (0.56) | MAPTCYP1A2CYP2D6CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298766-B1 | Pharmaceutical formulations comrpising a substituted pyridine derivative | LUNDBECK & CO AS H (DK) | 2013-09-18 | — | — | EP | disclosed |
| US-8299071-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2012-10-30 | — | — | US | disclosed |
| EP-2298766-A1 | Substituted pyridine derivatives | H. Lundbeck A/S (DK) | 2011-03-23 | — | — | EP | disclosed |
| US-20110003811-A1 | SUBSITUTED PYRIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2011-01-06 | — | — | US | disclosed |
| US-7812020-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2010-10-12 | — | — | US | disclosed |
| US-20080318953-A1 | Substituted Pyridine Derivatives | H. LUNDBECK A/S (DK) | 2008-12-25 | — | — | US | disclosed |
| EP-1861394-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006092143-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318953-A1 | Substituted Pyridine Derivatives | KCNQ2, KCNQ1, KCNQ5 | MAPT 1188/4885CYP1A2 801/4885CYP2D6 525/4885 |
| US-20110003811-A1 | SUBSITUTED PYRIDINE DERIVATIVES | KCNQ2, KCNQ1, KCNQ5 | MAPT 1133/4885CYP1A2 652/4885CYP2D6 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.