Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.57 |
| ▸ | NQO2 | P16083 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10536345 | 0.83 | ALDH1A1 (0.42) | TLR8ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL27929761 | 0.82 | TLR8 (0.47) | TLR8ALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL21200039 | 0.79 | PDGFRB (0.54) | NQO2ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19076211 | 0.79 | PDGFRB (0.55) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14911960 | 0.77 | TDP1 (0.53) | NQO2ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17255630 | 0.76 | TLR8 (0.50) | TLR8ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL17255631 | 0.76 | TLR8 (0.50) | TLR8ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL9590284 | 0.76 | TLR8 (0.67) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19076264 | 0.75 | MAPT (0.52) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5117776 | 0.74 | TLR8 (0.65) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678329-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012154274-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-15 | — | — | WO | disclosed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |