Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 8/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683733 | 0.88 | ABCB1 (0.36) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9683741 | 0.88 | ABCB1 (0.36) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684091 | 0.84 | ABCB1 (0.42) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684099 | 0.84 | ABCB1 (0.42) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684235 | 0.77 | KCNH2 (0.34) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684229 | 0.77 | KCNH2 (0.34) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9787439 | 0.77 | ABCB1 (0.46) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9787435 | 0.77 | ABCB1 (0.46) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684987 | 0.76 | ABCB1 (0.42) | ABCB1ADRB2ADRB1ADRB3 | |
| SCHEMBL9684985 | 0.76 | ABCB1 (0.42) | ABCB1ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |