Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 11/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL27340939 | 0.94 | — | — | |
| Histamine SCHEMBL5447892 | 0.94 | — | — | |
| Histamine SCHEMBL2279 | 0.94 | — | — | |
| Histamine SCHEMBL1668636 | 0.94 | HRH4 (0.42) | HRH3HRH4TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL7444650 | 0.94 | HRH4 (0.42) | HRH3HRH4TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL289072 | 0.94 | HRH4 (0.42) | HRH3HRH4TSHRCYP2C9CYP2C19 | |
| Imbutamine SCHEMBL3885328 | 0.92 | HRH1 (0.44) | HRH3HRH4HRH1HRH2 | |
| Histamine SCHEMBL4760179 | 0.91 | — | — | |
| Histamine SCHEMBL584026 | 0.91 | TDP1 (0.44) | HRH3HRH4TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL21806473 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113075196-B | Method for rapidly detecting biogenic amine in food by surface enhanced Raman scattering | 昆明理工大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-113075196-A | Method for rapidly detecting biogenic amine in food by surface enhanced Raman scattering | 昆明理工大学 | 2021-07-06 | — | — | CN | disclosed |
| US-5124358-A | Nematocides | THE BOARD OF REAGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 1992-06-23 | — | — | US | disclosed |