Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 12/20 | 0.87 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.87 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.87 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684040 | 1.00 | ADRB3 (0.87) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL9685312 | 1.00 | ADRB3 (0.87) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL11310357 | 0.93 | ADRB2 (1.00) | ADRB3ADRB2ADRB1CYP2D6SLC6A2 | |
| SCHEMBL10872071 | 0.93 | ADRB2 (0.76) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL10871762 | 0.93 | ADRB2 (0.76) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL10873688 | 0.88 | ADRB3 (0.68) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL10873682 | 0.88 | ADRB3 (0.68) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL10873694 | 0.88 | ADRB3 (0.68) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL11226058 | 0.88 | SLC6A2 (0.71) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL11218637 | 0.87 | ADRB3 (0.88) | ADRB3ADRB2ADRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | claimed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |