Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.63 |
| ▸ | METAP2 | P50579 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393939 | 0.85 | METAP2 (0.53) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL4394002 | 0.84 | METAP2 (0.57) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL3212638 | 0.84 | METAP2 (0.57) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL9220073 | 0.82 | CCR1 (0.65) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL2522559 | 0.81 | PLAU (0.58) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL1101005 | 0.81 | PARP1 (0.58) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL2781605 | 0.81 | METAP2 (0.53) | CCR1METAP2PLAUNCF1ALOX12 | |
| SCHEMBL10437729 | 0.80 | METAP2 (0.49) | CCR1METAP2PLAUNCF1ALOX12 | |
| Hydrochloric Acid SCHEMBL6535609 | 0.79 | METAP2 (0.52) | CCR1METAP2PLAUNCF1ALOX12 | |
| Hydrochloric Acid SCHEMBL1978354 | 0.79 | PLAU (0.56) | CCR1METAP2PLAUNCF1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104994853-A | Dihydro-6-azaphenalene derivatives for the treatment of cns, oncological diseases and related disorders | WARNER BABCOCK INST FOR GREEN CHEMISTRY LLC | 2015-10-21 | — | — | CN | disclosed |
| US-5082666-A | Drugs, sweeteners | LABORATOIRES BEAUFOUR (FR) | 1992-01-21 | — | — | US | disclosed |