Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29046091 | 0.87 | ALDH1A1 (0.56) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL30412573 | 0.87 | ALDH1A1 (0.56) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL1093120 | 0.86 | ALDH1A1 (0.97) | ALDH1A1HTTMAPK1MAPTPOLB | |
| SCHEMBL907889 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL4676953 | 0.85 | ALDH1A1 (1.00) | ALDH1A1HTTMAPK1MAPTPOLB | |
| SCHEMBL4679344 | 0.85 | ALDH1A1 (1.00) | ALDH1A1HTTMAPK1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL3174215 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL899829 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL903045 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTMAPK1ADRB1SIRT6 | |
| SCHEMBL13075786 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTMAPK1ADRB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |