Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685251 | 1.00 | HPGD (0.44) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9684937 | 0.84 | HPGD (0.49) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9684931 | 0.84 | HPGD (0.49) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL261445 | 0.81 | ALDH1A1 (0.61) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9685027 | 0.80 | ALDH1A1 (0.49) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL10728228 | 0.80 | ALDH1A1 (0.49) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9685022 | 0.80 | ALDH1A1 (0.49) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL10731118 | 0.78 | ALDH1A1 (0.47) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL10731111 | 0.78 | ALDH1A1 (0.47) | HPGDALDH1A1LMNAPRNPRECQL | |
| SCHEMBL9685098 | 0.74 | DHODH (0.38) | HPGDALDH1A1LMNAPRNPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |