Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 2/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10726091 | 1.00 | DHODH (0.36) | DHODHALDH1A1HPGDPOLBMAPT | |
| SCHEMBL10726039 | 0.86 | DHODH (0.38) | DHODHALDH1A1HPGDPOLBMAPT | |
| SCHEMBL9685098 | 0.86 | DHODH (0.38) | DHODHALDH1A1HPGDPOLBMAPT | |
| SCHEMBL10731053 | 0.75 | HPGD (0.41) | DHODHALDH1A1HPGDPOLBMAPT | |
| SCHEMBL10731065 | 0.75 | HPGD (0.41) | DHODHALDH1A1HPGDPOLBMAPT | |
| SCHEMBL9685535 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HPGDPOLBMAPTRECQL | |
| SCHEMBL10726013 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HPGDPOLBMAPTRECQL | |
| SCHEMBL10725715 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTRECQLBLM | |
| SCHEMBL7436196 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTRECQLBLM | |
| SCHEMBL8322191 | 0.69 | GAA (0.50) | ALDH1A1L3MBTL1GAAKMT2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |