Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465155 | 0.81 | KMT2A (0.57) | ALDH1A1KDM4ETHRBPOLBHTT | |
| SCHEMBL2562206 | 0.80 | ALDH1A1 (0.58) | ALDH1A1KDM4ETHRBPOLBGAA | |
| SCHEMBL12359542 | 0.77 | HTT (0.70) | ALDH1A1POLBGAAHTTMEN1 | |
| SCHEMBL29410065 | 0.76 | ALDH1A1 (0.74) | ALDH1A1KDM4EPOLBRECQLMAPT | |
| SCHEMBL6360360 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4EPOLBHTTMAPT | |
| SCHEMBL14679139 | 0.74 | KMT2A (0.67) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4983013 | 0.74 | KDM5B (0.54) | ALDH1A1POLBTDP1MAPK1 | |
| SCHEMBL24479699 | 0.74 | GAA (0.61) | ALDH1A1KDM4EPOLBGAAHTT | |
| SCHEMBL2562910 | 0.73 | ALDH1A1 (0.54) | ALDH1A1KDM4ETHRBPOLBGAA | |
| SCHEMBL18617529 | 0.73 | KMT2A (0.54) | ALDH1A1POLBHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |