SCHEMBL9686333

SCHEMBL9686333

COc1cccc(-c2ccccc2)c1.N=C=O.N=C=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
CYP1A1 P04798 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2E1 P05181 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C8 P10632 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2A6 P11509 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP4B1 P13584 1/20 0.52
CYP2B6 P20813 1/20 0.52
CYP3A5 P20815 1/20 0.52
CYP2A7 P20853 1/20 0.52
CYP3A7 P24462 1/20 0.52
CYP2F1 P24903 1/20 0.52
CYP2C18 P33260 1/20 0.52
CYP2C19 P33261 1/20 0.52
CYP2J2 P51589 1/20 0.52
CYP4F2 P78329 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30185444 0.94 HDAC4 (0.58) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
SCHEMBL9869408 0.94 HDAC4 (0.58) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
SCHEMBL14993 0.94 HDAC4 (0.58) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
SCHEMBL29740761 0.88 CYP1A1 (0.64) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
SCHEMBL458391 0.88 CYP1A1 (0.64) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
Formaldehyde SCHEMBL21629200 0.86 HDAC4 (0.58) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
SCHEMBL13247865 0.86 ABL1 (0.64) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
Methane SCHEMBL28582279 0.84 CYP1A2 (0.59) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
Hydrochloric Acid SCHEMBL28963139 0.84 CYP1A2 (0.59) HDAC4HDAC8CYP1A1CYP1A2CYP2E1
Methyl Alcohol SCHEMBL28369741 0.84 HDAC4 (0.59) HDAC4HDAC8CYP1A1CYP1A2CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5157097-A Reacting aromatic tricarboxylic acids, diisocyanates, diamines and end-blocking compounds; high glass transition temperature, heat resistant, melt moldable MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1992-10-20 US disclosed
EP-0472421-A2 Polyamide-imide resins and process of producing them MITSUI TOATSU CHEMICALS, Inc. (JP) 1992-02-26 EP disclosed