Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690740 | 0.95 | PIM1 (0.47) | RIPK1PIM1HRH3CYP1A2USP2 | |
| SCHEMBL382481 | 0.81 | JAK1 (0.54) | RIPK1KCNH2JAK1 | |
| Hydrochloric Acid SCHEMBL8130344 | 0.79 | JAK1 (0.53) | RIPK1KCNH2JAK1 | |
| Hydrochloric Acid SCHEMBL5007369 | 0.79 | JAK1 (0.53) | RIPK1KCNH2JAK1 | |
| Bromide SCHEMBL3874715 | 0.79 | JAK1 (0.53) | RIPK1KCNH2JAK1 | |
| SCHEMBL9690333 | 0.78 | PIM1 (0.50) | RIPK1PIM1DYRK1AKCNH2ROCK2 | |
| Water SCHEMBL9602231 | 0.77 | PIM1 (0.43) | RIPK1PIM1HRH3CYP1A2USP2 | |
| SCHEMBL9044459 | 0.75 | PTPN11 (0.48) | PIM1HRH3CYP1A2USP2ALDH1A1 | |
| SCHEMBL6797408 | 0.75 | PIM1 (0.43) | RIPK1PIM1HRH3CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL9691036 | 0.75 | NPC1 (0.50) | RIPK1PIM1KCNH2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |