⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792665 | 0.79 | ALOX5 (0.47) | — | |
| SCHEMBL8679784 | 0.78 | ALOX5 (0.40) | — | |
| SCHEMBL1756881 | 0.75 | — | — | |
| SCHEMBL10943898 | 0.75 | — | — | |
| SCHEMBL702163 | 0.75 | — | — | |
| SCHEMBL17694687 | 0.73 | TDP1 (0.45) | — | |
| SCHEMBL9768922 | 0.73 | — | — | |
| Methylene Chloride SCHEMBL27333999 | 0.72 | KDM4E (0.38) | — | |
| SCHEMBL3533840 | 0.71 | — | — | |
| SCHEMBL8675677 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |
| US-4004010-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1977-01-18 | — | — | US | disclosed |
| US-3998960-A | ANALGESIC, ANTITUSSIVE, OPIATE ANTAGONIST | BOEHRINGER INGELHEIM GMBH (DT) | 1976-12-21 | — | — | US | disclosed |
| US-3992542-A | Pharmaceutical compositions containing an N-(furyl-methyl)-6,14-(endoethano or endoetheno)-7α-hydroxyalkyl-tetrahydro-noroipavine or -northebaine and method of use | BOEHRINGER INGELHEIM GMBH (DT) | 1976-11-16 | — | — | US | disclosed |
| US-3975368-A | OPIATE ANTAGONIST, ANALGESICE, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-08-17 | — | — | US | disclosed |
| US-3931194-A | ANALGESIC, ANTITUSSIVE, OPIATE ANTAGONIST | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |
| US-3931187-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |
| US-3931189-A | ANALGESIC, ANTITUSSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |